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Faculty Image Brooke Martin
Office: Chem 207
Phone: 406-243-4546
Email: brooke.martin@umontana.edu

 

Description:

With a four year industry hitus  in the Paint and Pigment industry working for Dulux, ICI, Australia Dr. Martin's research has been in the area of metals - primarily toxic metals in biological systems.  This includes research in the laboratory of Dr. Peter Lay at the University of Sydney synthesizing novel Cr(V) compounds and studying chromium and vanadium mutation rates in Salmonella Typhimurium as well as a PhD with Dr. Karen Wetterhahn at Dartmouth College in 1998, looking into the toxicity and metabolism of chromium, arsenic and cadmium compounds in human lung cells. From 1998-2000 she was an American Heart Association Postdoctoral fellow in the Division of Cell Biology at the University of Utah Medical School, studying iron and copper metabolism and the way toxic metals could utilise essential metal delivery systems. Dr. Martin moved to the University of Montana in 2000 as a postdoctoral fellow in the laboratory of Dr. Kent Sugden. She is now a Research Associate Professor in the Department of Chemistry. 

Field Of Study:

Toxic metals in biologicals systems and the cellular response to DNA modification. 

Research Interests:

My research interest remains the study of toxic metals in biological systems, particularly with regard to modifcations of DNA and its consequences.  

Education:

Bachelor of Science (Hons); The University of Sydney, Australia 

PhD, Dartmouth College, NH, USA

American Heart Association Post-doctoral fellow; The University of Utah, UT, USA

Teaching Experience:

Bio-Inorganic Chemistry; Biochemistry; Analytical Chemistry; Metal Toxicology

Selected Publications:

Gremaud, J.G., Martin, B.D., Sugden, K.D.  2010 Influence of substrate complexity on the diastereo-selective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation. Chem. Res. Tox. 23, 379-385. 

Bergquist ER, Fischer RJ, Sugden KD, Martin BD. 2009 “Inhibition by methylated organo-arsenicals of the respiratory 2-oxo-acid dehydrogenases.” J Organomet Chem. 2009 Mar 15;694(6):973-980.

Hailer MK, Slade PG, Martin BD, Rosenquist TA and Sugden KD 2005 "Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2  2" DNA Repair 4(1) 41-50.

Hailer MK, Slade PG, Martin BD, and Sugden KD 2005 “Nei Deficient Escherichia coli Are Sensitive to Chromate and Accumulate the Oxidized Guanine Lesion Spiroiminodihydantoin” Chem. Res. Toxicol. 18(9), 1378-1383. and cover

Sugden KD, Campo CK, and Martin BD. 2001 “Direct Oxidation of Guanine and 7,8-dihydro-8-oxo-Guanine by a High Valent Chromium Complex” Chem. Res. Toxicol. 14(9) 1315-1322

Martin BD, Schoenhard JA and Sugden K D. 1998 “Hypervalent Chromium Mimics Reactive Oxygen Species as Measured by the Oxidant-Sensitive Dyes 2',7'-Dichlorofluorescein and Dihydrorhodamine” Chem. Res. Toxicol., 11(12) 1402-1410.

Other Publications:

Ardon OA, Kaplan J and Martin BD. 2002 “Iron Uptake in Yeast“ in Molecular and Cellular Iron Transport Marcell Dekker Templeton D ed. Chapter II.2

Sugden KD, Campo CK, and Martin BD. 2001 “Direct Oxidation of Guanine and 7,8-dihydro-8-oxo-Guanine by a High Valent Chromium Complex” Chem. Res. Toxicol. 14(9) 1315-1322

Martin BD, Schoenhard JA and Sugden K D. 1998 “Hypervalent Chromium Mimics Reactive Oxygen Species as Measured by the Oxidant-Sensitive Dyes 2',7'-Dichlorofluorescein and Dihydrorhodamine” Chem. Res. Toxicol., 11(12) 1402-1410.