Research
Pilot Project Leaders

Bruce E. Bowler, Department of Chemistry & Biochemistry
Project Title: Measuring biases in the denatured state ensemble of the three-helix bundle fold

Richard Bridges, Dept of Biomedical & Pharmaceutical Sciences
Co-Project Leader: Sarj Patel, Dept of Biomedical & Pharmaceutical Sciences
Project Title: Structure-function of the system xc- glutamate/cystine exchanger:
Identification of xct residues participating in binding and translocation

Michael Kavanaugh, Department of Biomedical and Pharmaceutical Sciences; Director, Center for Structural and Functional Neuroscience
Project Title: Biophysical mechanisms of glutamate transport

Project Title: Mechanism of novel inhibitors of Rift Valley fever virus nucleocapsid-RNA interactions

Brooke Martin, Department of Chemistry and Biochemistry
Co-Project Leader: Kent Sugden, Department of Chemistry and Biochemistry
Co-Project Leader: Katie Hailer, Department of Chemistry, Montana Tech of the University of Montana
Project Title: The role of the endonuclease VIII (nei) operon in processing of DNA damage and cell survival

Michele McGuirl, Division of Biological Sciences
Co-Project Leader: Lara M. Taubner, Division of Biological Sciences
Project Title: Structural and physiologic consequences of native post-translational modifications of the prion protein: a mechanism for toxicity

Michael F. Minnick, Division of Biological Sciences
Project Title: Structural and functional analysis of a unique, metal-binding surface protein of Coxiella burnetii

Brent Ryckman, Division of Biological Sciences
Project Title: Structure-function analysis of a cytomegalovirus CC chemokine
Andrea Stierle, Dept. of Biomedical and Pharmaceutical Sciences
Co-Project Leader: Donald Stierle, Dept. of Biomedical and Pharmaceutical Sciences
Co-Project Leader: Teri Girtsman, Dept. of Biomedical and Pharmaceutical Sciences
Project Title: The use of caspase-1 inhibition and the mitigation of interleukin-1β production by induced inflammasomes to isolate compounds with anti-inflammatory and anticancer activity from symbiotic bacteria of the human gut microbiome

Celestine J. Thomas, Division of Biological Sciences
Co-Project Leader: Jack Nunberg, Montana Biotechnology Center
Project Title: Characterization of liposome fusion by a fusion-active Arenavirus envelope glycoprotein



